The stimulate angiogenesis effect of bone marrow stem cell mobilization on the hearts of myocardial infarction rats
10.3760/cma.j.issn.1008-6706.2009.08.002
- VernacularTitle:骨髓干细胞动员疗法对心肌梗死大鼠心肌的促血管生成作用
- Author:
Yu ZHANG
;
Min YANG
;
Chang CHEN
;
Chunyin YAN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Myelold progenitor cells;
Regeneration of myocardium and neovascularization;
Cinsenoside;
Simvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(8):1347-1348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the stimulate angiogenesis effect of bone marrow stem cell mobilization on coronary collateral development in the hearts of experimental myocardial infarction rats.Methods Left anterior descending coronary arteries were ligated to produce acute myocardial infarction(AMI)model in Wistar rats.Bone marrow stem cells were mobilized and home to the site of myocardial infarction by ginsenoside Rgl and Simvastatin.Hearts were harvested in the 24th hour,1st and 4th week after AMI modeling for histopathological examination.Immu nohistochemisty were used to detect infiltration of CD+34 cells and the expression of VⅢ factor in the part of ischemia.And infarct area were measured.Results Infarct area in mobilized group was obviously less than in AMI group.There were a great number of monocytes infiltrating with CD34 expression by immunohistochemisty in myocardial infracted zone in mobilized rats.Capillary density in mobilized group was greater than those of AMI and sham-operated groups.Conclusion In the AMI model of rat,bone marrow stem cells can be mobilized by ginsenoside Rgl and Simvastatin.The capillary density can be increased by mobilizing bone marrow stem cells.Ginsenoside Rgl and Simvastatin can improve the acute ischemic cardiac function by enhancing angiogenesis.
