Therapy with continous intravenous infusim pralidoxime chloride therapy in acute organophosphorus pesticide poisoning
10.3760/cma.j.issn.1008-6706.2009.08.025
- VernacularTitle:氯磷定持续静脉泵入治疗急性有机磷农药中毒51例分析
- Author:
Xianyin JIN
;
Jun HE
;
Jianbin WANG
- Publication Type:Journal Article
- Keywords:
Pralidoxime chloride;
Continuous infusion therapy;
Organophosphorus pesticide;
Poisoning
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(8):1385-1386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of continuous intravenous pralidoxime chloride infusion in acute organophosphorus pesticide poisoning(AOPP).Methods The patients with severe AOPP were randomly divided into 3 groups:(1)group 1(n =51)received a bolus injection of pralidoxime chloride 2.Og followed by continuous intravenous infusion at 0.25 g/h.(2)group 2(n = 51)received a bolus injection of pralidoxime 2.Og followed by continuous intravenous infusion at 0.5g/h.(3)group 3(n = 50)received intravenous drip of pralidoxime 2.Og for 3 times a day.Efficacy was compared among 3 groups on the basis of time to reach atropinization,recovery of cholinesterase activity .cumulative amount of atropine,incidence of recurrence of pesticide poisoning,intermediate syndrome,and hospitalization days,etc.Results Efficacy in patients receiving continuous intravenous therapy was significantly different from the third group.But there was no significant difference in efficacy between the first and second groups.Conclusion The patients with AOPP can be effectively treated by a loading dose followed with continous intravenous pralidoxime chloride infusion.
