Assessmant of the influences of pentafluoropropyloxydihydroartemisinin and mefloquin on functions of the nervous system in rats
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
pentafluoropropyloxydihydroartemisinin, mefloquin
- MeSH:
Mefloquine;
Nervous System;
Rats;
drugs;
animals;
Artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;3():40-47
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
A assessment of influences of pentaflouropropyloxydihydroartemisinin (BB.103) and mefloquine on functions of the nervous system of rats. The results showed that: BB.103 with doses 50mg/kg x 5 days (1 and 2 times), and mefloquine doses 50mg/kg x 5 days were found not to influence conditional reflex of rats. The changes of speed of establishment of reflex, speed of establishment of stable reflex, time of consolidation of reflex were found to be unstatically significant as compared to the control. BB.103 with doses 100mg/kg x 5 days (1 and 2 times), and mefloquine doses 100mg/kg x 5 days was found to influence the time of establishment of conditional reflex of rats. The changes were statically significant compared with control group
