High glucose stimulates the expression of transforming growth factor-β1 and fibronectin via SREBP-1 in HKC cells
10.3760/cma.j.issn.1000-6699.2009.04.027
- VernacularTitle:高糖通过SREBP-1促进人肾小管上皮细胞转化生长因子β1和纤维黏连蛋白表达
- Author:
Jun HAO
;
Jinping ZHANG
;
Jiangbo GU
;
Shuxia LIU
;
Huijun DUAN
- Publication Type:Journal Article
- Keywords:
High glucose;
HKC cells;
SREBP-1;
Transforming growth factor-β1;
Fibronectin
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(4):442-444
- CountryChina
- Language:Chinese
-
Abstract:
significantly increased (all P < 0.01). Following SREBP-1 was down-regulated by siRNA, high glucose-stimulated TGF-β1 and FN protein expressions were decreased by 17.9% and 24.6% ,respectively(all P<0.01).
