Expression of thymidine phosphorylase in hepatocellular carcinoma and its clinical significance
10.3760/cma.j.issn.1007-8118.2009.08.005
- VernacularTitle:原发性肝癌组织中胸苷磷酸化酶的表达及其临床意义
- Author:
Weifan LIU
;
Changneng KE
;
Rongjiang LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Prognosis;
Angiogenesis;
Thymidine phosphorylase;
Microvessel density
- From:
Chinese Journal of Hepatobiliary Surgery
2009;15(8):571-574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the significance of thymidine phosphorylase for prognosis of HCC.Methods The clinical data and pathological finding of 65 patients with HCC treated in our hospital were retrospectively analyzed.Immunohistochemical staining was performed to evaluate the expression of TP and MVD count.Statistical analysis was used to analyze the relationship between TP expression and other pathological parameters.Survival curves in 54 patients were plotted using the Kaplan-Meier method.Results The positive expressed rate of HCC tissues was significantly higher than that of normal liver tissues (P<0.01).MVD count in positive-TP group and negative-TP group was respectively 16.14±5.11,10.11±4.55.The difference between two groups had statistical significance (P<0.01).TP expression was positively correlated with tumor size,Edmondson-Steiner grade,tumor capsule status,microsatellite marker and tumor thrombi in portal vein (TTPV).The rate of postoperational recurrence after one,two and three years in TP-positive group was respectively 40%,66.7%,79.2% and it was respectively 27.4%,31.3% and 45.7% in TP-negative group.The postoperative recurrence rate after two years and three years in poitive-TP group was significantly higher than that in negative-TP group (P<0.01).In 54 patients with HCC followed up successfully,the total survival rate in TP-positive group was significantly lower than in TP-negative group (P<0.01).Conclusion TP plays an important role in neovascularization of HCC and TP may be a new prognosis index of HCC.
