Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis
- VernacularTitle:低分子量肝素诱导重症急性胰腺炎大鼠胰腺腺泡细胞凋亡的实验研究
- Author:
Qinqiao FAN
;
Shuwei CHEN
;
Genhui YANG
;
Bo LIU
;
Wensheng CAO
;
Yi YU
;
Xinsheng LU
;
Liqiao FAN
- Publication Type:Journal Article
- Keywords:
Heparin,low-molecule-weight/PD;
Pancreatitis/PP;
Pancreas/CY;
Apoptosis
- From:
Journal of Chinese Physician
2009;11(3):342-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of LMWH therapy for SAP.Methods 48 wistar rats were random divided into 3 groups,sham group(S group),severe acute pancreatitis group(SAP group)and LMWH therapy group(H group).Serum amylase,IL-6,acinar cell apoptosis and the activity of NF-κB were detected and compared.Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group(P＜0.01).The apoptosis index of acinar cell in SAP group wag significantly lower than that in H group(P＜0.01),while the activity of NF-κB in SAP groupwas stronger than that in H group.Conclusions LMWH therapy may ameliorate SAP by inducing acinar cell apoptosis through suppressing the activity of NF-κB.
