The Comparison of Mydriatic Effect Between Two Drugs of Different Mechanism.
- Author:
Ji Hyun PARK
1
;
Young Chun LEE
;
Se Youp LEE
Author Information
- Publication Type:Original Article ; Comparative Study
- Keywords: Pupil dilation; 1% tropicamide; 2.5% phenylephrine
- MeSH: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Muscarinic Antagonists/*administration & dosage; Mydriatics/*administration & dosage; Ophthalmic Solutions; Phenylephrine/*administration & dosage; Pupil/*drug effects; Refractive Errors/diagnosis/physiopathology; Retrospective Studies; Tropicamide/*administration & dosage; Young Adult
- From:Korean Journal of Ophthalmology 2009;23(1):40-42
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To maximize effective use of mydriatic drugs through comparing the pupillary dilation effects between 1% tropicamide and 2.5% phenylephrine. METHODS: Fifty people requiring pupillary dilation were divided into 3 groups. Group 1 was treated with one drop of 1% tropicamide in the right eye and one drop of 2.5% phenylephrine in the left eye. Group 2 was treated twice during a 5-minute interval with 1% tropicamide in the right eye. Group 3 was treated twice during a 5-minute interval with 2.5% phenylephrine in the right eye. Groups 2 and 3 were treated with 2.5% phenylephrine and 1% tropicamide in the left eye, administered during a 5-minute interval. The pupillary size was measured in all groups for 40 minutes following eye drops administration. RESULTS: The mean patient age was 15.7 years. Group 1 included 10 patients, and groups 2 and 3 included 20 patients each. Eight patients in group 1 and 16 patients in group 2 developed a larger right pupil. Fourteen patients in group 3 developed a larger left pupil. CONCLUSIONS: Our study showed that 1% tropicamide, with its parasympathetic antagonistic mechanism of action, was more effective at inducing pupillary dilation than 2.5% phenylephrine, and the combination of 1% tropicamide and 2.5% phenylephrine was more effective than multiple drops of single eye drops.
