Expression of estrogen receptor and progesterone receptor in different tumor tissues of invasive ductal carcinoma of breast

VernacularTitle:乳腺癌肿瘤组织不同部位雌孕激素受体的表达
Author: Bin GU ; Jianzhong CHEN ; Xin ZHANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Estrogen receptor; Progesterone receptor
From: Journal of International Oncology 2011;38(1):78-80
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of estrogen receptor (ER) and progesterone receptor (PR) in different tumor tissues of invasive ductal carcinoma(IDC) of the breast. Methods A total of 32 cases of IDC samples were collected. ER and PR expressions in 4 different sites of every sample were measured by immunohistochemical(IHC) assays. Results Overall, a high concordance in both estrogen receptor and progesterone receptor expressions are observed between different tumor tissue sites. The best Kappa values were 0.789 and 0.810 for ER and PR expression respectively. The worst Kappa values were 0. 563 and 0.672,respectively. Conclusion ER and PR expression is not significantly different in different tumor tissues of the same IDC sample. Repeated testing in different tumor tissue sites has little contributions in clinical settings.