Application of adipose-derived stem cells in cartilage tissue engineering
10.3760/cma.j.issn.1673-4181.2009.04.008
- VernacularTitle:脂肪干细胞在软骨组织工程中的应用
- Author:
Hengyun SUN
;
Guangdong ZHOU
;
Yilin CAO
- Publication Type:Journal Article
- Keywords:
Adipose stem cells;
Cartilage tissue engineering;
Seeding cells
- From:
International Journal of Biomedical Engineering
2009;32(4):224-227
- CountryChina
- Language:Chinese
-
Abstract:
Cartilage is one of the earliest reconstructed tissues used in tissue engineering. Due to the lack of appropriate seeding cells, cartilage tissue engineering is, however, relatively lagged behind. With the emergence of stem cell research, adipose stem cells(ASCs) are introduced as seeding cells into tissue engineering for possessing many advantages such as wide spreading, large amount of cells available and easy to obtain. However, the outcome of tissue engineered cartilage construction by ASCs is not as ideal as that by bone marrow stem cells (BMSCs) yet. Low efficiency of ASC chondrogenesis is considered the major cause. This review summarizes the purification of adipose-derived cells, maintenance of sternness and optimization of ehondrogenie induction, which play vital roles in improving ASC s chondrogenesis.
