Topical and Oral Voriconazole in the Treatment of Fungal Keratitis.
- Author:
Sang Joon LEE
1
;
Jung Joo LEE
;
Shin Dong KIM
Author Information
- Publication Type:Case Report
- Keywords: Fungus; Keratitis; Voriconazole
- MeSH: Administration, Oral; Antifungal Agents/*administration & dosage; Candidiasis/diagnosis/*drug therapy/microbiology; Cornea/microbiology/pathology; Diagnosis, Differential; Dose-Response Relationship, Drug; Eye Infections, Fungal/diagnosis/*drug therapy/microbiology; Follow-Up Studies; Humans; Keratitis/diagnosis/*drug therapy/microbiology; Male; Middle Aged; Ophthalmic Solutions; Pyrimidines/*administration & dosage; Triazoles/*administration & dosage
- From:Korean Journal of Ophthalmology 2009;23(1):46-48
- CountryRepublic of Korea
- Language:English
- Abstract: We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
