Roles of basic fibroblast growth factor in the seft-renewal of human embryonic stem cells
10.3760/cma.j.issn.1673-4181.2009.04.015
- VernacularTitle:bFGF在人胚胎干细胞中自我更新的研究进展
- Author:
Yanwei WANG
;
Jianyuan LI
- Publication Type:Journal Article
- Keywords:
Basic fibroblast growth factor;
,Human embryonic stem cells;
Fibroblast growth factor receptors;
Self-renewal
- From:
International Journal of Biomedical Engineering
2009;32(4):251-255
- CountryChina
- Language:Chinese
-
Abstract:
The self-renewal and multi-lineage developmental potential are the unique properties of human embryonic stem(ES) cells. The growth factors that maintain human or mouse embryonic stem cells are different. Leuckemia inhibitory factor(LIF) does not maintain self-renewal of human ES cells(hESCs). Recently, a few growth factors have been found to be biologically relevant for hESCs functions in vitro, among them the basic fibroblast growth factor(bFGF) is one of the most significant regulators of hESCs self-renewal. The purpose of this review is to introduce the recent progress in the research on the expressions of bFGF and its receptors and their functions in hESCs.
