Efficacy of enternal nutrition support with high-energy density nutrition emulsion in severely burned patients
10.3760/cma.j.issn.1674-635X.2009.01.004
- VernacularTitle:高能量密度营养乳剂的肠内营养对严重烧伤患者的临床疗效
- Author:
Tianzhi HAO
;
Jingmin ZHU
;
Wenbo HU
;
Hua ZHANG
;
Zhenhui GAO
;
Xuehui WEN
;
Jingjie LIU
;
Zhi ZHOU
;
Gang LU
- Publication Type:Journal Article
- Keywords:
Bums;
Glutamine;
Hydroxyproline
- From:
Chinese Journal of Clinical Nutrition
2009;17(1):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of glutamine dipeptide on wound healing after operations on bums. Methods Totally, 30 burned patients were randomly divided into study group and control group (15 cases in each group). All patients received parental nutrition support after operation. Study group patients were supplemented with glutamine dipeptide at a dose of 0. 5 g · kg±1 · d±1. The plasma free hydroxyproline level was measured by a standard amino acid analyzer 1 day before operation and 7 days after operation and the wound healing time was recor± ded. Results The plasma free hydroxyproline levels of both groups were higher than the normal values before opera± tion but without significant difference [control group: (2. 24 ±0. 84) fig/ml, study group: (2. 32 ±0.92) μg/ml, normal value: (1.27 ±0.44) μg/ml]. On the post±operative 7 day, the plasma free hydroxyproline level of study group [ (4. 31 ±1. 05) μg/ml] was significantly higher than that of control group [ (3. 04± 1. 01) μ/ml] (P = 0.002). The wound healing time of study group [ (29. 7±5.3) d] was shorter than that of control group but with± out significant difference [ (33. 3 ±7.5) d, P = 0. 14 ]. Conclusion The intravenous supplementation of glutamine dipeptide may increase the plasma hydroxyproline level after operation and thus promote wound healing.
