Assessment of virulence and potential risk of direct transmission to human of 2004-2005 virus H5N1 in Southern Vietnam through surveillance and genetic analysis
- Author:
Cao Thi Bao Van
- Publication Type:Journal Article
- Keywords:
H5N1 viruses;
Transmision;
Human;
Transmutation;
- MeSH:
Influenza A Virus, H5N1 Subtype;
Humans
- From:Journal of Preventive Medicine
2005;15(6):5-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Genomes of 24 human and avian H5N1 influenza viral strains in the Southern area of Vietnam during the 2004-2005 outbreaks were sequenced completely. All viruses containing multiple basic amino acids at the hemagglutinin cleavage site HA1-HA2 are associated with a highly pathogenic phenotype. A series of amino acid mutations located in NSl and PB2 proteins were associated with the possibility of efficient replication in mammalian tissue. The mutation in the receptor binding sites of HA that could affect binding process to human cells was found from isolates in 2004-2005 Avianflu outbreaks. All isolates are belonging to Z genotype. The findings indicated that H5Nl viruses in Vietnam have changed to be more infectious to human host in 2004-2005 Avianflu outbreaks.
