Pathophysiological mechanisms of cognitive impairment caused by chronic cerebral hypoperfusion
10.3760/cma.j.issn.1673-4165.2009.08.012
- VernacularTitle:慢性脑缺血导致认知障碍的病理生理学机制
- Author:
Junjie XIAO
;
Yan CHENG
;
Qing ZHAN
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
cognition disorders
- From:
International Journal of Cerebrovascular Diseases
2009;17(8):614-617
- CountryChina
- Language:Chinese
-
Abstract:
Chronic cerebral hypoperfusion is a common pathological state. Cognitive impairment is its main manifestation in early stage, and it will eventually result in persistent or progressive cognitive impairment and neurological deficits. Chronic cerebral hypoperfusion caused neuronal damage, synapse abnormity, energy impairment and the function defects of central cholinergic system and monoaminergic system are its pathophysiological mechanisms resulting in cognitive impairment.
