Rho kinase and ischemic cerebrovascular disease
10.3760/cma.j.issn.1673-4165.2009.08.015
- VernacularTitle:Rho激酶与缺血性脑血管病
- Author:
Weiwei LIU
;
Guiyun CUI
;
Xia SHEN
- Publication Type:Journal Article
- Keywords:
rho-associated kinases;
cerebral ischemia;
cerebrowascular disorders
- From:
International Journal of Cerebrovascular Diseases
2009;17(8):626-635
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic cerebrovascular disease may result in severe neurological deficits, and even death. Rho kinase is an important downstream substrate of Rho protein. It involves in multiple biological effects, including vascular smooth muscle contraction, cell migration, inflammatory cell infiltration and vascular endothelial dysfunction. It plays important roles in the processes of the occurrence, development and expansion of infarct volume in ischemic cerebrovascular disease. Rho kinase inhibitor can effectively relax vascular spasm, reduce local inflammatory response, protect endothelial function, increase blood flow in ischemic region, reduce infarct volume, and improve neurological function.
