Mycological profile of cryptococcal meningitis in patients with non-acquired immune deficiency syndrome during treatment and follow-up
10.3760/cma.j.issn.1000-6680.2009.09.008
- VernacularTitle:非艾滋病患者隐球菌脑膜炎治疗与随访过程中真菌学指标分析
- Author:
Yuanjie ZHU
;
Junyong ZHANG
;
Julin GU
;
Jianghan CHEN
;
Hang XU
;
Jin ZHAO
;
Yun QIU
;
Hai WEN
- Publication Type:Journal Article
- Keywords:
Meningitis;
cryptococeal;
Acquired immunodeficiency syndrome;
Staining and labeling;
Mycology;
Follow-up studies
- From:
Chinese Journal of Infectious Diseases
2009;27(9):540-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine mycological profile of eryptococcal meningitis in patients with non-acquired immune deficiency syndrome (AIDS) during treatment and follow-up so that to support clinical therapy. Methods Data of 28 cuhure-confirmed cryptoeoccal meningitis patients with non-AIDS were retrospectively analyzed. Fungat smear, count, culture and latex agglutination test of cerebrospinal fluid (CSF) were done during treatment and follow-up. Initial treatment included intravenous amphotericin B plus oral flucytosine or f;uconazole for at least 6 weeks, and consolidation treatment included oral fluconazole and (or) itraeonazole for at least 2 months. All 28 patients were cured. The data were analyzed by rank-sum test. Results The positive rate of CSF fungal smear was 92.9% before treatment and gradually decreased, and the fungal count was significantly reduced over time after treatment. While fungal smears of some patients were still positive after initial treatment. Fungal growth time in culture was gradually extended, and fungal culture turned to be negative in all patients after 2 weeks of treatment. The positive rate of latex agglutination test of CSF was 100%. Cryptococcal antigen titer decreased steadily after treatment, which was not correlated with the decrease of fungal count. Conclusion Mycological tests of patients with eryptococcal meningitis should be interpreted comprehensively during treatment, and result of each test should be specifically analyzed.
