Blood Lead Level as a Predictor of Coronary Artery Disease.
- Author:
Ryoung Jin PARK
1
;
Seung Hyun KIM
;
Ji Ung PARK
;
Yang Hyun KIM
;
Myoung Bo KIM
;
Won Ju PARK
;
Jai Dong MOON
Author Information
1. Department of Occupational and Environmental Medicine, Chonnam National University College of Medicine, Korea. jdmoon@chol.com
- Publication Type:Original Article
- Keywords:
Blood lead;
Coronary artery stenosis;
Coronary artery calcification
- MeSH:
Adult;
Angiography;
Cardiovascular Diseases;
Coronary Artery Disease;
Coronary Stenosis;
Coronary Vessels;
Electrocardiography;
Female;
Humans;
Hypertension;
Male;
Multivariate Analysis;
Occupational Exposure;
Peripheral Arterial Disease
- From:Korean Journal of Occupational and Environmental Medicine
2009;21(1):38-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Lead exposure is known to be associated with high blood pressure, hypertension, coronary artery disease, peripheral arterial disease, left ventricular hypertropy, and electrocardiographic abnormalities. We investigated the association between blood lead and coronary artery calcification and stenosis. METHODS: Between April 2006 and July 2007, 502 adults (345 males and 157 females), who had no history of cardiovascular disease or occupational exposure to lead, were recruited as study subjects. All subjects underwent coronary CT angiography and blood lead measurement. RESULTS: Blood lead levels were distributed from 0.43 to 11.30 (microgram/dL with a geometric mean blood lead level of 2.98+/-1.5 (microgram/dL. The geometric mean blood lead levels were higher in men than women (3.31+/-1.5 (microgram/dL vs. 2.36+/-1.5 (microgram/dL, P < 0.01). Based on a multivariate analysis, a 1 unit ((microgram/dL) increase in blood lead level was associated with a 1.09 (95% confidence interval, 0.92~1.29) and a 1.01 fold (95% confidence interval, 0.63~1.63) greater risk for coronary artery calcification in men and women, respectively. Similarly, a 1 unit (microgram/dL) increase in blood lead level was associated with a 1.25 (95% confidence interval, 1.03~1.51) and a 1.42 fold (95% confidence interval, 0.73~2.75) greater risk for coronary artery stenosis in men and women, respectively. CONCLUSIONS: The results suggest that increased blood lead levels are associated with an increased risk of coronary artery stenosis.
