Effects of low frequency repetitive transcranial magnetic stimulation on motor function and affective disorder in patients with Parkinson's disease
10.3760/cma.j.issn.0254-9026.2009.09.008
- VernacularTitle:低频重复经颅磁刺激对帕金森病运动功能和情感障碍的疗效观察
- Author:
Mingwei WANG
;
Ping GU
;
Xiaowei MA
;
Yanmin LI
;
Yanyong WANG
;
Jihong GUO
;
Huijun WANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Movement disorders;
Mood disorder;
Transcranialmagnetic stimulation
- From:
Chinese Journal of Geriatrics
2009;28(9):729-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on motor function and affective disorder in patients with Parkinson's disease (PD). Methods Twenty PD patients were performed by 1 Hz rTMS therapy for 15 days and 10 matched patients were performed sham stimulation. Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Unified Parkinson' s Disease Rating Scale (UPDRS) were assessed before and 15 days after rTMS treatment. Results After treatment with rTMS, the motor function was improved, and UPDRS total score and UPDRS-Ⅰ , UPDRS-Ⅱ, UPDRS-Ⅲ scores were decreased. UPDRS score was decreased from (38.45±17.33) to (30.95± 17.00) (t=6.780,P<0.01). At the same time, HAMD score was decreased from (12.15±7.62) to (8.75±7.31 ) (t = 5.101, P<0.01 ). The scores of somatization, blockage and sleep disorders were lowered after treatment, but the HAMA score had no significant change(t=1.757, P>0.05). The rigidity of PD patients was improved obviously. All indexes had no improvement in sham stimulation group. Conclusions Low frequency rTMS may improve motor dysfunction and affective disorder in PD patients .
