Clinical analysis of 21 patients with multisystemic invasive fungal diseases
10.3760/cma.j.issn.1000-6680.2009.09.009
- VernacularTitle:多系统侵袭性真菌病21例临床分析
- Author:
Feifei YANG
;
Liping ZHU
;
Yuxian HUANG
;
Shu CHEN
;
Weimin JIANG
;
Jiming ZHANG
;
Guangfeng SHI
;
Xinhua WENG
- Publication Type:Journal Article
- Keywords:
Nosomycosis;
Prognosis;
Immune system;
Cryptococcus neoformans;
Immunosuppressive agents
- From:
Chinese Journal of Infectious Diseases
2009;27(9):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features, diagnosis, treatment and prognosis of muhisystemic invasive fungal diseases. Methods Twenty-one patients with multisystemic invasive fungal diseases who were hospitalized in department of infectious diseases from January 2001 to June 2008 were retrospectively reviewed. The pathogenic bacteria, involved organs, underlying diseases, clinical manifestations, treatments and prognoses of muhisystemic invasive fungal diseases were analyzed. Results Among 21 recruited cases, 17 had underlying diseases and 11 were treated with long-term immunosuppressive agents. The main pathogenic bacteria were Cryptococcus neoformans, Aspergillus and Candida parapsilosis. Lung and brain were involved in 16 cases (skin involve in 2 cases and lymph node involved in 1 case simultaneously), lung and lumbar involved in 2 cases, heart valves involved in 2 cases, and liver, spleen and bone marrow involved in 1 case. Eight cases were cured, 6 were improved and 7 died. Conclusions In this study, most of the 21 cases with multisystemic invasive fungal diseases are immunocompromised. The main pathogenic bacterium is Cryptococcus neoformans. The lung and brain are common organs involved. Prognosis is associated with early diagnosis and active anti-fungal treatment.
