Relationship between ceramide, gastrins and colorectal neoplasms
10.3760/cma.j.issn.1673-4203.2009.09.013
- VernacularTitle:胃泌素及神经酰胺与大肠肿瘤的关系
- Author:
Changsheng YU
;
Pei WU
- Publication Type:Journal Article
- Keywords:
gastrins;
ceramides;
colorectal neoplasms;
signal transduction
- From:
International Journal of Surgery
2009;36(9):612-614
- CountryChina
- Language:Chinese
-
Abstract:
It is confirmed that expression of gastrins in some colorectal neoplasms cells and their tissue is abnormal. The abnormal expression of gastrins have close relationship with the occurrence and the develop-ment of colorectal neoplasms. Gastrins binding with receptor can regulate ceramides content and promote cells proliferation by series of signal transduction pathways. Blocking these signal transduction pathways may provide a novel therapeutic approach for colorectal neoplasms prevention and treatment.
