The study on plasma adiponectin levels and risk of colorectal cancer
10.3760/cma.j.issn.1673-4203.2009.05.008
- VernacularTitle:血清脂联素与大肠癌关系的研究
- Author:
Zhijun HU
;
Bo LI
;
Yu WANG
;
Qi ZHENG
;
Yang ZOU
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
adiponectin;
ELISA
- From:
International Journal of Surgery
2009;36(5):308-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective By comparing the plasma levels of adiponectin respectively in colorectal carcinoma patients to healthy controls to discuss the relationship between adiponectin and colorectal carcinoma. Methods Plasma samples collected from 38 colorectal cancer cases, 38 healthy controls, respectively, were analyzed with a specific ELISA assay. Results The mean adiponectin levels in colorectal cancer pa-tients and healthy controls were 159.89 and 184.5 pg/mL,respectively. Obviously colorectal cancer patients had significantly lower plasma adiponectin concentrations compared with healthy controls(P=0.001). And a inverse correlation was found between plasma adiponectin levels and tumor size with significantly lower levels of adiponectin in tumors≥5 cm (P=0.04), while no similar relationship was found between adiponectin and p53, Dukes stages(P>0.05). Conclusions Lower plasma levels of adiponectin are associated with color-ectal carcinogenesis closely. And the lower plasma levels of diponectin were positively related to the degree of tumor size. It can presume that adiponectin play a vital role in the process of colorectal carcinogenesis.
