Bioartificial kidney alters cytokine response and survival time in acute uremic pigs with multiple organ dysfunction syndrome
10.3760/cma.j.issn.1671-0282.2009.09.010
- VernacularTitle:生物人工肾对急性肾衰并多器官功能障碍猪的细胞因子反应性及存活时间的影响
- Author:
Hengjin WANG
;
Xiaoyun WANG
;
Miao ZHANG
;
Xumin YING
;
Huijuan MAO
;
Wenbin ZHU
;
Chen SUN
- Publication Type:Journal Article
- Keywords:
Interleukin-10;
Tumor necrosis factor-α;
Bioartificial kidney;
Multiple organ dysfunction syndrome;
Survival time
- From:
Chinese Journal of Emergency Medicine
2009;18(9):937-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of bioartificial kidney(BAK)treatment on cytokines interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α),biochemistry indexes,and survival time in acute uremic pigs with multiple organ dysfunction syndrome(MODS).Method Pigs with MODS and acute renal failure(ARF)were treated with BAK(group A,n = 6)or sham BAK containing no cells(group B,n = 6)or received no treatment(group C,n = 5).Data on blood pressure,hepatic and renal functions,serum IL-10 and TNF-α levels,arterial blood gas and survival time of all the pigs were recorded.Comparisons of values were done using Student's t-test or repeated-measures analysis of variance(ANOVA).ResultsMean arterial pressure(MAP,mmHg)responsed more rapidly and reached higher values in group A (91.82±5.73)compared with group B and C at 24 hours(P＜0.01).The peak level of serum EL-10(pg/mL)ingroupA(249.57±43.51)was significantly higher than that in group B and C(132.06± 17.53,104.25 ±13.42,P＜0.01).Serum TNF-a level(pg/mL)in group A dropped gradually to(402.91 ± 32.47)at 24 hours,and had significant discrepancy compared with that before the treatment(537.16 ± 38.45)and that in groupB(P＜0.05).The average survival time(hours)in group A(113.01 ± 14.32)was significantly longer than that in the group B and C(P＜0.01),which was prolonged by 35.93%and 63.90%,respectively.ConclusionsTreatment with BAK can prolong the survival time of uremic pigs with MODS,possibly through ameliorating the MAP,increasing the level of IL-10 and reducing the concentration of TNF-α.
