The study on the change of plasma endothelin-1 related with pulmonary function in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4904.2009.27.004
- VernacularTitle:慢性阻塞性肺疾病患者血浆内皮素-1含量与肺功能变化的研究
- Author:
Linong YU
;
Jian HAO
;
Xiaowei PENG
;
Yawei SHEN
;
He HUANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Endothelins;
Blood gas analysis;
Pulmonary function
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(27):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of content of plasma endothelin(ET)-1 with the change of pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Method Thirty cases of the normal people were as group A ,34 cases of the patients with COPD with acute exacerbation before treatment were as group B and the patients with remission period after treatment were as group C,the plasma ET-1,arterial blood gas and pulmonary function parameters were determined from the patients before and after treatment.Results The plasma ET-1 in group B and group C were significantly higher than that in group A,the content of the plasma ET-1 had negatively correlated with PaO2,and that had positively correlated with PaCO2,P＜0.01.The pulmonary function parameters (VC,FEV1/FVC,MVV,V50 V25)in group B were significantly lower than those in group A and group C[(55.3±24.5)%,(54.8±19.3)%,(54.2±16.2)%,(54,8±9,9)%,(58.7±14.5)%;(114.8±24.1)%,(84.9±21.6)%,(86.4±17.2)%,(78.5±14.8)%,(90.3±15.4)% and (110.1±19.4)%,(85.8±15.5)%,(85.9±16.7)%,(74.5±13.4)%,(89.4±18.6)%,respectively],P＜0.01.Conclusion Pathophysiological effects of patients with COPD can be commonly adjusted by the plasma ET-1,oxygen and carbon dioxide retention,which affect pulmonary function.
