Safety and efficacy of intra-arterial infusion neoadjuvant chemotherapy for local advanced bladder cancer
10.3760/cma.j.issn.1000-6702.2009.10.013
- VernacularTitle:局部晚期膀胱癌术前动脉灌注新辅助化疗的安全性与疗效分析
- Author:
Yinong NIU
;
Yong YAN
;
Junhui ZHANG
;
Ning KANG
;
Jianwen WANG
;
Xiquan TIAN
;
Xuehe WANG
;
Nianzeng XING
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Chemotherapy,adjuvant
- From:
Chinese Journal of Urology
2009;30(10):681-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of intra-arterial infusion neoadiuvant chemotherapy in local advanced bladder cancer. Methods Nineteen cases with T2-T4a bladder cancer were enrolled in this study.Intra-arterial infusion chemotherapy with Gemcitabine and Cisplatin (GC)were performed for 1 to 3 cycles before radical cystectomy.Postoperative values of hematological parameters,maximum diameter of tumors,TNM(tumor,node and metastasis)stages and pathological grades were compared with preoperative parameters of the same case. Results Compared to the values before GC chemotherapy,WBC count showed no significant change post-operative,(6.63±2.58)×109/L vs(5.12±2.91)×109/L(P=0.13);RBC(4.41+0.52)×1012/L vs(3.92±0.42)×1012/L(P=0.00)and platelet count(220.50±59.86)×109/L vs(157.05±56.72)×109/L(P=0.001)showed significant decrease;ALT did not show significant decrease(20.00±8.31 vs 26.88±17.04 U/L,P=0.08);Creatltme also showed no significant change(95.82±14.57 vs 88.04±17.76μmol/L,P=0.06);Maximum diameter of tumors decreased significantly(3.72±1.23 vs 2.80±1.29 cm,P=0.02).Compared with clinical TNM stages,pathological TNM stages demonstrated significant decrease in 9 cases;While cell differentiation did not show decrease. Conclusions Intra-arterial infusion with GC regimen can reduce tumor size,decrease TNM stages,while not causing significant adverse impact to radical cystectomy.Bladder-spare treatment is an option for chemotherapy-sensitive cases.
