Determination of serum sFas and sFasL in the clinical research before and after treatment of uterine cervix cancer
10.3760/cma.j.issn.1673-4904.2009.27.005
- VernacularTitle:宫颈癌治疗前后检测血清sFas、sFasL的临床研究
- Author:
Liulian FENG
;
Hongfang ZHANG
;
Xiaoping FENG
;
Chuping WANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Surgical procedures,operation;
Chemotherapy;
Serum
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(27):14-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of sFas and sFasL in the development and progression of uterine cervix cancer(UCC)and the clinical significance of detecting them.Method Serum sFas and sFasL levels of 30 UCC patients were detected by enzyme-linked immunosobent assay (ELISA) before and after treatment (operation or chemotherapy),at the same time serum sFas and sFasL levels of 20 healthy volunteers were also detected by ELISA.Results Serum sFas and sFasL levels of UCC patients[(8.60±0.27),(2.96±0.65)μg/L] were obviously higher than those of healthy volunteers[(6.27±0.25),(0.21±0.05)μg/L],there was statistical significance (P＜0.05).Serum sFas and sFasL levels of those who had operations decreased obviously 2 weeks after the operation,serum sFas and sFasL levels of those who had chemotherapy 3 weeks later increased,there was statistical significance when compared before and after treatment (P＜0.05).Conclusions sFas and sFasL may play important roles in the development and progression of UCC,detection of serum sFas and sFasL levels may conduce to observe the changes of pathogenetic condition.
