Effect of flurbiprofen axetil and fentanyl of postoperative analgesia on T-lymphocytes subtypes in patients undergoing esophagectomy
10.3760/cma.j.issn.1673-4904.2009.27.007
- VernacularTitle:氟比洛芬酯复合芬太尼术后镇痛对食管癌根治术患者T淋巴细胞亚群的影响
- Author:
Yunfei ZHANG
;
Yanping FENG
;
Tingkun LI
;
Yi ZHOU
- Publication Type:Journal Article
- Keywords:
Flurbiprofen;
Fentanyl;
Analgesia;
T-lymphocytes
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(27):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of flurbiprofen axetil and fentanyl of postoperative analgesia on T-lymphocytes subtypes in patients undergoing esophagectomy.Methods Forty patients undergoing esophagectomy were randomly divided into two groups(20 cases each):group C (group fentanyl) was given fentanyl 20μg/kg plus tropisetron 5 mg diluted to 100 ml via PCIA after surgery,group F (group flurbiprofen-fentanyl) was administrated flurbiprofen axetil 50 mg at 30 min before the end of surgery,fentanyl 10μg/kg and flurbiprofen axetil 100 mg plus tropisetron 5 mg diluted 100 ml was administrated via PCIA after surgery.The PCIA rate was 2 ml/h,bolus 0.5ml,lock time 15 min.The VAS score was recorded at 12,24,48 h after surgery.Blood samples 2 ml were obtained from peripheral vein for determination of CD3+,CD4+,CD8+ and CD4+/CD8+ at 30 min before surgery(T0),24 h(T1)and 72 h(T2)after surgery.Results Patients in two groups did not show any significant difference in the VAS scores(P＞0.05).At T1 CD3+,CD4+ T-lymphoeytes were significantly lower than those at T0 in two groups(P＜0.05).At T2,CD3+,CD4+ T-lymphocytes in group F were significantly higher than those in group C(P＜0.05).In group C,CD3+,CD4+ T-lymphocytes at T2 were significantly decreased than those at T0(P＜0.05).CD8+ T-lymphocytes Was no significantly changed in two groups and at each time point determined (P＞0.05).Conclusion Postoperative analgesia by using flurbiprofen axetil and fentanyl can diminish the using dose of postoperative opioid drug,and it can'improve patient's cellular immune function.
