Treatment of effects of mixtures of pethidine and haloperidol about treatment for Postoperative Delirium

VernacularTitle:杜氟合剂治疗手术后谵妄的效果观察
Author: Yinghong GU ; Naiquan MA ; Shaochuan FU ; Qi ZHOU
Publication Type:Journal Article
Keywords: Anesthesia; Delirium,Haloperidol; Pethidine
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(9):1582-1583
CountryChina
Language:Chinese
Abstract: Objective To explore the dose and effects of mixtures of pethidine and haloperidol for Postoperative Deliri-um. Methods Retrospective analysis was conducted on treatment dose and effects of 85 cases of patients with deliri-um during narcotic awake period or 1 day to 2 days after operation by mixtures (haloperidol with pethidine) from 2005 to 2006 in Affiliated Hospital of Hainan Medical College. Results 1/4 dose of mixture (pethidine 100 mg and haloperidol 5 mg) cured 9 patients, 1/2 dose of mixture cured 61 cases, we add 1/4 dose of mixture when 10 cases occurred delirium again ,5 cases added 1/2 dose of mixture again, all were cured. After administration ,aublood pres-sure declined all, but all were within normal range, the 17 cases's pulse oxygen saturation is less than 95%, Conclu-sion The mixture (haloperidol with pethidine) can be effective treatment for delirium during awake period of general anesthesia or after operation. However, application of low dose therapy from the beginning, and attention to its impact on respiration.