Randomized control study on the effect of sequential therapy and standard triple therapy on eradication of Helicobacter pylori
10.3760/cma.j.issn.1673-4904.2009.28.002
- VernacularTitle:序贯疗法与标准三联疗法根除幽门螺杆菌疗效随机对照研究
- Author:
Liangping LI
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Peptic ulcer;
Sequential therapy
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(28):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect,adverse reaction and coat of sequential therapy (including lansoprazole,amoxicillin,clarithromycin and tinidazole) and standard triple therapy (including lansoprazole,amoxieillin and clarithromycin) for eradication of Hehcobacter pylori (Hp).Methods Eighty-six patients with Hp positive peptic ulcer and chronic gastritis were randomized into two groups.Study group (45 cases) were treated with lansoprazole plus amoxicillin at first 5 days,lansoprazole,clarithromycin and tinidazole at the second 5 days.Control group (41 cases) were treated with lansoprazole,amoxicillin and clarithromyein for 10 days.Results The eradication rates of Hp in study group were 88.89% (40/45,95% CI 76.00%-96.00%) and 93.33% (42/45,95% CI 82.00%-98.00%),and those in control group were 78.05% (32/41,95% CI 78.04%-90.72%) and 85.37% (35/41,95% CI 85.37%-96.19%) with intention-to-treat and perprotocol analysis respectively.The differences between two groups were significant (P＜0.05).The incidence rate of adverse reaction was 4.44% (2/45) in study group and 14.63% (6/41) in control group respectively.The cost in study group was cheaper than that in control group.Conclusion Ten days sequential therapy is higher in eradication rate of Hp,well-tolerated and cheaper.
