Expression and significances of β-catenin in Barrett esophagus and esophageal adenocarcinoma
10.3760/cma.j.issn.1673-4904.2009.28.007
- VernacularTitle:β-连环蛋白在Barrett食管及食管腺癌中的表达及临床意义
- Author:
Wanli WANG
;
Li WEI
;
Fan ZHANG
- Publication Type:Journal Article
- Keywords:
Beta catenin;
Barrett esophagus;
Esophageal neoplasms;
Immunohisto chemistry
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(28):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of the expression of β-catenin(β-cat) in Barrett esophagus and esophageal adenocarcinoma (EAC) and the relationship between its expression and clinicopathological factom.Methods By using SP immunohistochemistry technique,β-cat wag detected in the normal esophageal mucosa group (20 cases),Barrett esophagus with dysplasia group (26 cages) and EAC group (50 cases).Results The membranous expression of β-cat appeared in all of nomal esophageal mucosa.The rate of cytoplasmic and/or nuclear expression of β-cat in the Barrett esophagus with dysplasia group and the EAC group was 38.5% (10/26) and 60.0% (30/50) respectively,and compared with the normal esophageal mucosa group,the difference was signfficant (P＜0.01).The rate of cytoplasmic and/or nuclear expression of β-cat in the EAC group with lymphatic metastasis and the EAC group exceeding deep smooth muscle was 90.0% (18/20) and 72.2%(26/36) respectively,and compared with that in the nonlymphatic metastasis and the non-exceeding deep smooth muscle patients [43-3%(13/30) and 28.6% (4/14)],the difference was significant (P＜0.01).Conclusion Cytoplasmic and/or nuclear expression of β-cat might play a role in the carcinogenesis and progression of EAC and might be a predictor indicating the metastatic potential of EAC.
