Effect of oxygen therapy on SOD and MDA of rabbits exposed to mimic acute hypoxia
10.3760/cma.j.issn.1672-7088.2009.10.009
- VernacularTitle:氧疗对模拟急性高原缺氧兔超氧化物酶及丙二醛的影响
- Author:
Min ZHANG
;
Jingci ZHU
;
Yanni YANG
- Publication Type:Journal Article
- Keywords:
Oxygen therapy;
Hypoxia;
SOD;
MDA
- From:
Chinese Journal of Practical Nursing
2009;25(28):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of SOD and MDA after the rabbits were exposed to acute hypoxia when cured by oxygen therapy.Methods New Zealand rabbits underwent hypoxia imitating the 4500-meter sea level in altitude chamber(group E,n=6),then some received oxygen therapy,the volume ratio of oxygen-nitrogen mixture was 25%,30% and 35% respectively for 10,5 and 3 hours as group B,C and D.Another 5 rabbits received no treatment as normal group.The rabbits samples were collected at the time points of 1,3,5,10 and 24 hours after the oxygen therapy started to detect serum biochemical indicators.Results Comparing with normal control group,serum SOD activity in simple hypoxia group noticeably decreased and the content of MDA noticeably increased;in three oxygen therapy groups,serum SOD activity in 25% oxygen therapy group was highest and the content of MDA was lowest.Serum SOD activity in 25% oxygen therapy group had ascendant tendency and the content of MDA had descendant tendency.Conclusions Low concentration oxygen therapy can prevent acute hypoxia-induced injury in rabbits,besides increase oxygen partial pressure,oxygen therapy may improve superoxide dismutase activity.
