The relation of early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient and body weight changes following intensification therapy of insulin
10.3760/cma.j.issn.1008-6315.2009.10.020
- VernacularTitle:初发糖尿病患者胰岛素强化治疗后胰岛B细胞早期分泌功能恢复与体重变化的关系
- Author:
Lixin YANG
;
Yaping ZHANG
;
Na MI
;
Ye WANG
;
Qinfang ZHU
;
Weiliang HAN
;
Yinjuan LI
- Publication Type:Journal Article
- Keywords:
Diabetes;
Insulin;
Beta cell function
- From:
Clinical Medicine of China
2009;25(10):1061-1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of early time secretion function of Beta cell in newly diag-nosed type 2 diabetic patient and the changes of body weight following intensification therapy of insulin. Methods 237 newly diagnosed type 2 diabetic patients were divided into 1 kg lower group, the 1-5 kg group, the 5 kg above group. The maximum body weight and waist circumference were recorded. The present body weight and waist circum-ference were measured according to OGTT study, meanwhile,30 minuets blood sugars, the insulin and the C-peptide (C-P) level and the blood pressure(BP) and the insulin resistance index (HOMA-IR), the early insulin secretion index (△I30/△G30) was calculated. All cases were treated for 14 days. Results Early time secretion function of Beta cell in the group keeping above lose weight 5 kg was the worst, after treatment insulin secretion level were in-creased 1.12 times and 1.86 times in 1 kg lower group than in the 1-5 kg group and above 5 kg group. Conclusions Early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient is correlated with the maxi-mum body weight decrease.
