Study of pathogen aetiology and drugs resistance in neonatal septicemia
10.3760/cma.j.issn.1008-6315.2009.10.038
- VernacularTitle:新生儿败血症血培养菌株近七年的变迁及耐药分析
- Author:
Yuxia YANG
;
Junying QIAO
;
Bin LUAN
;
Xinxia WANG
- Publication Type:Journal Article
- Keywords:
Neonate;
Septicemia;
Blood culture;
Drug resistance
- From:
Clinical Medicine of China
2009;25(10):1103-1105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study pathogen aetiology and distribution of drug resistance in neonatal septice-mia. Methods A retrospective study of positive organisms of blood cultures and the results of antimicrobial suscep-tibility testing was conducted from January 2000 to December 2006 in 1293 cases of neonatal septicemia;The results were divided into three groups:the earlier group,the middle group and the later group. The strains were identified by VITEK-AMS and antibiotics susceptibility was tested by K-B method, results were interpreted according to NCCLS. inant in three groups(76.3% ,74.1% and 65.7% ) (P <0.05). Among Gram-pesitive coccus,the most prevalent strains was staphylococcus, Gram-negative bacilli increased gradually,accounting for 21.3% ,21.3% and 28.4% in cpidermids to erythromycin and sulfamethoxazole/trimethoprim were rather higher:93.3% ,73.7% vs 87.8% vs 100.0%, respectively, the resistance -rates to penicillin were less,but to susceptible to vancomyein,piperacill/tazo-batam,amikacinand ciprofloxacin;gram-negative bacilli were only sensitible to imipenem, cefepime, and cefopera zone/sulbactam;multiresistances of drug strains was commonly seen. Condusions It is important for using antibi-otics rationally according to drug sensitivity test, because multiresistant strains and opportunistic pathogen are com-monly seen.
