Staphylococcal scalded skin syndrome in patients with hematologic malignancy: a report of 4 cases

VernacularTitle:血液恶性肿瘤患者并发葡萄球菌性烫伤样皮肤综合征四例并文献复习
Author: Jingzhi WANG ; Lanping XU ; Huan CHEN ; Daihong LIU ; Kaiyan LIU ; Xiaojun HUANG
Publication Type:Journal Article
Keywords: Staphylococcal scalded skin syndrome; Hematologic neoplasms; Graft vs host disease
From: Chinese Journal of General Practitioners 2009;8(10):706-709
CountryChina
Language:Chinese
Abstract: Objective To investigate the development of Staphylococcal scalded skin syndrome (SSSS) in patients with hematologic malignancy. Methods The clinical data of 4 cases of SSSS admitted from November 2006 to June 2008 were analyzed, and the related literatures were reviewed. Results Four patients developed SSSS all under severe immunosuppression. Two of them were in neutropenia, and the others had been intensively treated for severe graft versus host disease. They presented high fever and erythema, followed by the formation of flaccid bullae and exfoliation. Three patients recovered successfully with the treatment of vancomycin and intravenous administration of immunoglobulin. Withdraw of mmunosuppressive agents in patients following hematopoietie stem cell transplantation was helpful. Conclusions SSSS should be considered when high fever and erythema suddenly occur in patients with hematologic malignancy.