The risk factors of nocturnal hypoglycemia in elderly patients with type 2 diabetes

VernacularTitle:60岁及以上2型糖尿病患者发生夜间低血糖的危险因素分析
Author: Xiaoye HE ; Yu HU
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Hypoglycemia
From: Chinese Journal of General Practitioners 2009;8(10):736-738
CountryChina
Language:Chinese
Abstract: This study was to evaluate the risk factors of nocturnal hypoglycemia in elderly patients with type 2 diabetes by continuous glucose monitoring system. Fifty-one type 2 diabetic patients aged 60 or above were enrolled and the episodes of nocturnal hypoglycemia were documented. The risk factors of nocturnal hypoglycemia were analyzed by logistic regression and the cut-off of glucose levels at bedtime for nocturnal hypoglycemia was evaluated. There were twenty-two patients with total 681 nocturnal hypoglycemic episodes. Logistic regression analysis showed that the lowest glucose level at bedtime was the risk factor of nocturnal hypoglycemia (OR=0.36, 95% CI:0.13-1.00, P<0.05), while the gender, age, diabetes duration, therapy regimen, the highest and average glucose levels at bedtime were not associated to nocturnal hypoglycemia. Receiver operating characteristic curve (ROC) showed that the bedtime glucose at≤6.2 mmol/L was the best cut-off point for predicting nocturnal hypoglycemia.