Expression and clinical significance of PI3K and MMP-7 proteins in esophageal squamous cell carcinoma.
10.3760/cma.j.issn.1008-6315.2009.10.029
- VernacularTitle:食管鳞癌组织中PI3K和基质金属蛋白酶-7的表达及其临床意义
- Author:
Lei WANG
;
Xinqiang NIU
;
Baoen SHAN
;
Ming HE
;
Xianli MENG
;
Bing ZHANG
;
Shijie WANG
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
PI3K;
MMP-7;
Immunohistochemistry
- From:
Clinical Medicine of China
2009;25(10):1083-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of PI3K and MMP-7 in esophageal carcinoma and the rela-tionship between the expression of PI3K and MMP-7 and carcinogenesis and progression of esophageal carcinoma. Methods PI3K and MMP-7 expression were detected in 24 normal esophageal mucosa,94 primary tumor tissues with SP immunohistochemistal method. Results There were significant differences of PI3K and MMP-7 expressions between esophageal carcinoma and normal mucesa epithelium ( all P < 0.01 ) [71.28% (67/94) vs 4.17% ( 1/24 ) and 52.13% (49/94) vs 0% (0/24)]. There were significant correlations between PI3K expression and the degrees of differentiation,invasive depth,clinical staging and the metastasis of lymph node (all P <0.01 ). The positive ex-pression rate of MMP-7 had the relationship with metastasis of lymph node (P < 0.05 ), the degrees of differentiation ( P < 0.05 ) invasive depth ( P < 0.01 ), and clinical staging( P < 0.05 ) . There was a positive relationship between PI3K and MMP-7 expression in this study (r = 0. 232 ,P = 0.025). Conlusions PBK and MMP-7 play an impor-tant roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomarkers to eval-uate biological characteristics in esophageal squamous cell carcinoma.
