Effect of Shenqi Jiangtang Keli on Atherosclerotic Changes of Lower Extremities in Patients with Early Type 2 Diabetes Mellitus

VernacularTitle:参芪降糖颗粒对2型糖尿病早期下肢动脉粥样硬化的影响
Author: Yiwei ZHOU ; Jianhua GUO ; Changsong MA ; Jie SUN
Publication Type:Journal Article
Keywords: Shenqi Jiangtang Keli; Type2 diabetes mellitus; Atherosclerotic disease of lower extremities
From: International Journal of Traditional Chinese Medicine 2009;31(5):408-409
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of Shenqi Jiangtang Keli (SJK) on atherosclerotic disease (LEAD) of lower extremity in patients with early type 2 diabetes meliitus (T2DM). Methods The patients were randomly assigned to a control group and a treatment group. The 30 patients in the treatment group were treated by SJK and the 30 in the control group were given Cilostazo, with both groups were treated for 3 months. Lower extremity vascular color Doppler image, blood levels of interleukin-6 (IL-6) were measured before and after the treatment,. Results The thickness of atherosclerosis (AS) plaque and arterial intimamedia were obviously reduced (t=3.376, 3.468, P< 0.05 ), serum levels of IL-6 were also be lowered obviously (t=3.345, P<0.05) in the treatment group. While these indexes remained unchanged in the control group. Conclusion SJK has remarkable action in reducing the thickness of AS plaque and intima-media of artery. Its mechanism might be related with reducing serum IL-6 level.