Study on the Antivirus Effects of Keerkang Oral Liquid on Extracorporeal Bacteriostasis
10.3760/cma.j.issn.1673-4246.2009.05.005
- VernacularTitle:咳尔康口服液体外抗病毒作用的研究
- Author:
Yongcun HUANG
;
Liqun SUN
;
Bo HUANG
;
Zhenying NING
;
Lili GAO
;
Xiudong JIN
- Publication Type:Journal Article
- Keywords:
Keerkang oral liquid: cell culture
- From:
International Journal of Traditional Chinese Medicine
2009;31(5):397-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the inhibitive effect of Keerkang Oral Liquid on adenovirus (ADV3) , parainfluenza virus (HVJ) , respiratory syncytial virus (RSV) , and herpes simplex virus 1 (HSV-1) , herpes simplex virus 2 ( HSV-2 ) in cell culture. Methods Sensitive cell culture was adopted, and chick embryo kidney (CEK) cells and bit hamster kidney (BHK) cells were used to infect homologous virus. Keerkang Oral Liquid was given after 2 hours, then cytopathie phenomenon (CPE) was observed. Results When the amounts of infected virus are less than or equal to 100TCID50, the group which was given Keerkang Oral Liquid showed CPE, while the virus control group showed 25%～75% CPE. Besideds Keerkang Oral Liquid showed inhibitive effect on maximum non-venom concentration (TD0) , medium effective concentration (IC50), minimum valid concentration (MTC) and therapeutic index (TI) ofADV3, HVJ, RSV, BSV-1, and HSV-2 by 0.5, 0.25, 0A25-0.0625 ml/ml and 4.8 respectively. Conclusion Keerkang Oral Liquid has obvious inhibitive effects on ADV3, HVJ,RSV and HSV-1, HSV-2 in cell culture, which provides experimental basis for treating ADV3, HVJ, RSV and HSV-1, and HSV-2.
