Cross-sectional study of serum uric acid level in patients with chronic kidney disease and its influence fac-tors
10.3760/cma.j.issn.1008-6315.2009.10.014
- VernacularTitle:慢性肾脏病不同分期血尿酸的变化及其影响因素分析
- Author:
Xun LIU
;
Hua TANG
;
Hui PENG
;
Chenggang SHI
;
Zhujiang CHEN
;
Tanqi LOU
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
Serum uric acid;
Glomerular filtration rate;
Cross-sectional study
- From:
Clinical Medicine of China
2009;25(10):1048-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To present the baseline characteristics of serum uric acid level in patients with chro-nic kidney disease(CKD). Methods A cross-sectional study on CKD patients was carried out in our hospital for 9 months. Results 713 patients were enrolled. The top three causes of CKD in these patients were primary glomerular disease(61.2%, 436/713), essential hypertensive kidney disease (7. 2%, 51/713 ) and diabetic nephropathy (5.8% ,41/713). Serum uric acid level and the incidence of hyperuricemia were associated with the stage of CKD (F = 73. 569, P = 0. 000;χ2= 138. 156, P = 0.000). A significantly negative correlation was discovered between ser-um uric acid level and the level of glomerular filtration rate(RR = - 1. 045 ,P =0. 000). A significantly positive cor-relation of serum uric acid level was found with diastohc blood pressure, proteinuia level, smoking and BMI ( RR = 1.400,15. 149,37. 696,and 3.421 ,P <0.05 ,respectively). Conclusions The cross-sectional study of serum uric acid level in patients with CKD will help to determine the dynamic changes of serum uric acid level in Chinese CKD patients and lay a solid basis for the prevention and treatment of CKD and its complications.
