A clinical analysis of 20 cases with bone marrow granulomas

VernacularTitle:骨髓肉芽肿病20例临床分析
Author: Jun FENG ; Hong ZHANG ; Dingrong ZHONG
Publication Type:Journal Article
Keywords: Bone marrow; Granuloma; Diagnosis,differential; Tuberculosis
From: Chinese Journal of Internal Medicine 2009;(6):485-487
CountryChina
Language:Chinese
Abstract: Objective To study the clinical feature and original diseases of bone marrow granulomas. Methods A total of 5217 bone marrow biopsies were retrospecitively analyzed in Peking Union Medical College Hospital from January 2001 to December 2007. Results Bone marrow granulomas were present in 20 cases, representing an incidence of 0.38% in the series and an annual incidence of 2. 9 cases per year. Finally, 13 of these cases (65%) were diagnosed with tuberculosis. Hematological neoplasms and viral hepatitis were found in 4 and 2 cases respectively. Acute interstitial nephritis was diagnosed in one case. Conclusions The finding of a granuloma in a bone marrow biopsy is not common and unspecific.Tuberculosis, hematological neoplasms and viral hepatitis are the most common underlying diseases. Bone marrow biopsy is an important method for the diagnosis of disseminated tuberculosis.