The nervous system adverse effect induced by β-lactam antibiotics in patients on hemodialysis
10.3760/cma.j.issn.1008-6315.2009.07.027
- VernacularTitle:β-内酰胺类抗生素致血液透析患者神经系统不良反应
- Author:
Yu PENG
;
Qizhan LIN
- Publication Type:Journal Article
- Keywords:
β-lactam antibiotics;
Adverse effect;
Nervous system;
Renal failure;
Hemodialysis
- From:
Clinical Medicine of China
2009;25(7):739-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the reasonable utilization of β-lactam antibiotics in patients with renal failure on hemedialysis. Methods The clinical characteristics of patients with renal failure on hemodylysis,who de-veloped the adverse effect of nervous system and psychiatric symptom while being treated with β-lactam antibiotics,were retrospectively analyzed. Results The adverse effect of nervous system and psychiatric symptom showed dur-ing and after hemodialysis,including: mental confusion,hyperexcitabiliy,incoherent speech,lethargy and amyestasia in two cases. Physical examination did not show signs of cerebral focal injury in all cases. Computed tomography of brain in 7 patients did not show acute lesions. The symptoms completely disappeared after withdrawal of β-lactam antibiotics but bemodialysis or hemodiafiltration continued. Conclusion β-lactam antibiotics used in conventional dose could cause temporary adverse effect of nervous system in patients with renal failure on bemodialysis,which is related to prolongation of drug half life.
