Effects of thymosin alpha-1 on T cell subsets and gastricintestinal reaction of patients with gastricintestinal tumor
10.3760/cma.j.issn.1008-6706.2009.07.044
- VernacularTitle:胸腺肽α-1对胃肠道肿瘤化疗患者T淋巴细胞亚群和胃肠道反应的影响
- Author:
Shubang CHENG
;
Chengyou WANG
;
Min XU
;
Ying QIN
;
Haoyuan DENG
- Publication Type:Journal Article
- Keywords:
Gastricintestinal tumor;
Thymosin alpha-1;
T cell subsets
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(7):1220-1221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of thymosin alpha-1 on T cell subsets and gastricintestinal reac-tion of patients with gastricintestinal tumor. Methods Twenty patients with gastricintestinal tumor were divided into two groups, observe group(n = 10) received thymosin alpha-1 during chemotherapy, and control group(n = 10) only received chemotherapy, T cell subsets and gastricintestinal reaction were observed. Results Before chemotherapy, CD+4,CD+8 and CD+4/CD+8 of observe group were(43.7±7.5),(27.3±2.8) and (1.5±0.1), and control group were (39.4±6.3), (30.9±2.5) and (1.2±0.6). There was significant difference between them (P < 0.05). After chemotherapy, CD+4, CD+8 and NK cell were (40.6±6.8)、( 29.7±2.6) and (19.1±2.7), control group (35.9±5.7), (33.4±2.4) and (18.6±2.3). There was significant difference between them (P < 0.05). Effec-tive ratio of nausea and vomit of observe group were 72.5% and 60.0%, control group 40.0% and 33.3%, There were significant differences between them(P <0.05). Conclusion Thymosin alpha-1 may ameliorate the function of T cell subsets and gastricintestinal reaction of patients with gastricintestinal tumor.
