The therapeutic effects of three-dimensional conformal radiation therapy combined with transcathe-ter arterial chemoembolization for stage Ⅱ primary liver cancer
10.3760/cma.j.issn.1004-4221.2009.06.474
- VernacularTitle:肝动脉栓塞化疗联合三维适形放疗治疗Ⅱ期原发性肝癌疗效分析
- Author:
Fan LOU
;
Yongxing BAO
;
Yongjian NIU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms/radiotherapy;
Radiotherapy,three-dimensional conformal;
Liver neoplasms/chemotherapy;
Chemotherapy,embolization;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2009;18(6):474-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects of three-dimensional conformal radiation therapy (3DCRT) in combination with transcatheter arterial chemoembolization (TACE) for stage Ⅱ primary liver cancer. Methods Eighty-one patients were retrospectively analyzed, including 36 received 3DCRT combined with TACE (Group A) and 45 received TACE alone (Group B). The short-term therapeutic effects and 1-, 2-, 3-year survival rates, average survival time of the dead patients, and side effects were compared between the two groups. Results The follow-up rate was 100%. The numbers of patients finished 1-, 2- and 3-year follow-up were 55,19 and 6,respectively. The reponse rates were 72% in group A, and 60% in group B, which were not significant different (χ~2= 1.32, P > 0.05). The 1-, 2- and 3-year survival rates of the dead patients were 83%, 63% and 25% in group A and 75%, 37% and 8% in group B. The corresponding average survival time was 21 months and 16 months, respectively. The differences of 2- and 3-year survival rates were significant between group A and B. (χ~2= 4.87, P < 0. 05 ). The incidence and se-verity of side effects did not differ significantly between the two groups. Conclusions In patients with stage Ⅱ primary liver cancer, 3DCRT combined with TACE, being more effective than TACE alone, can prolong the long-term survival without increasing the toxicities.
