Relative study of chemosensitivities of peripheral blood lymphocytes and cancer cells of lung cancer in vitro

VernacularTitle:肺癌细胞与外周血淋巴细胞体外药敏实验的研究
Author: Shiqiang ZHANG ; Dongbo CHEN ; Baoqing WANG ; Lansheng ZHANG ; Haiqing WANG
Publication Type:Journal Article
Keywords: Lymphocytes; Carcinoma,cell; Drug sensitivity assay
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(9):1548-1549
CountryChina
Language:Chinese
Abstract: Objective To evaluate the correlation of chemosensitivity of cancer cells and peripheral blood lymphocytes to 8 chemotherapy agents in vitro,which was helpful to guide clinical chemotherapy for patients with lung cancer. Methods The chemosensitivity of the peripheral blood lymphocytes and tumor cells to 8 clinical routine che-motherapeutic agents was tested in 40 cases of lung cancer by using MTT method. SPSS 10. 0 was used to analyze the above indicators. Results There was no significant difference in the sensitivity of 8 clinical routine chemotherapeutic agents between peripheral blood lymphocytes and tumor cells of patients with lung cancer(P > 0. 05) ,which was posi-tive correlated to chemotherapeutic drugs between peripheral blood lymphocytes and tumor cells. Conclusion The chemosensitive test of the peripheral blood lymphocytes with MTT method in vitro was valuable for reference of selec-ting anticancer drugs in clinic for patients with lung cancer.