Relationship between expressions of CXCR4, MMP-2 and VGEF and biological behavior of pancreatic cancer
10.3760/cma.j.issn.1674-1935.2009.05.015
- VernacularTitle:胰腺癌CXCR-4、MMP-2、VEGF的表达及其与肿瘤生物学行为的关系
- Author:
Yujun LI
;
Xia LI
;
Lingling SUN
;
Wenwen RAN
;
Weiwei FU
;
Xiaoming XING
;
Zibin TIAN
- Publication Type:Journal Article
- Keywords:
Pancreatie neoplasms;
Immunohistochemistry;
Neoplasm inetastasis;
CXCR-4;
MMP-2;
VEGF
- From:
Chinese Journal of Pancreatology
2009;9(5):334-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CXCR4,MMP-2 and VEGF in pancreatic carcinoma and the relationship with biological behavior of pancreatic carcinoma.Methods Immunohistochemical PV6000 technique was used to detect the expression of CXCR4,MMP-2 and VEGF in 47 cases of pancreatic carcinoma tissues,and the relationship between the expressions and pathologic parameters,and the relationship among the expressions of the 3 proteins were analysed.Results The expression rates of CXCR-4,MMP-2 and VEGF were 72.3%,66.O%and 61.7%in pancreatic carcinoma tissues,and all these proteins were correlated with metastasis,clinical staging and prognosis(X2=5.84～12.69;P＜0.05).The expression of CXCR-4,MMP-2 and VEGF was not correlated with sex,age,tumor size and differentiation(X2=0.03～4.27;P＞0.05).There was a positive relationship between the expression of CXCR-4 and MMP-2 or VEGF in pancreatic carcinoma(r=0.587,0.521;P＜0.01).Conclusions CXCR-4 could up-regulate the expression of MMP-2 and VEGF in pancreatic carcinoma,and they may contribute to metastasis and invasion of pancreatic carcinoma.
