Aspirin resistance and ischemic cerebrovascular events
10.3760/cma.j.issn.1673-4165.2009.09.009
- VernacularTitle:阿司匹林抵抗与缺血性脑血管事件
- Author:
Qingxian LIU
;
Yongjian SONG
- Publication Type:Journal Article
- Keywords:
aspirin;
drug resistance;
platelet activation;
cerebral ischemia;
cerebral infarction
- From:
International Journal of Cerebrovascular Diseases
2009;17(9):690-695
- CountryChina
- Language:Chinese
-
Abstract:
Aspirin is a primary and secondary preventive medication for ischemic cerebrovascular diseases .Artery thrombotic events are still possible to occur after taking aspirin for a long time,and this indicates aspirin resistance(AR).At present, there is still lack of gold standard for the diagnosis of AR. It is usually interpreted as the loss of the biological effect of aspirin's antiplatelet aggregation and the role of preventing cerebral thrombosis events. Once AR occurs, other safe and effective altematives to antiplatelet agents should he used timely. This article reviews the concept, epidemiology, mechanisms, laboratory methods for detection and clinical intervention of AR.
