Cost-effectiveness analysis of morphine-midazolam, propofol and midazolam used for sedation in ICU patients with mechanical ventilation
10.3760/cma.j.issn.1008-6315.2009.11.003
- VernacularTitle:吗啡-咪达唑仑与普鲁泊福、咪达唑仑在机械通气患者镇静中的成本-效果分析
- Author:
Hualing WANG
;
Shenghu HE
;
Ruiqiang ZHENG
;
Qihong CHEN
- Publication Type:Journal Article
- Keywords:
Propofol;
Midazolam;
Morphine;
Sedation
- From:
Clinical Medicine of China
2009;25(11):1126-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the cost-effectiveness of Morphine-midazolam, propofol and midazolam used for sedation in patients with mechanical ventilation. Methods Ninety-three patients with mechanically ventila-Morphine-midazolam group:priming dose 0.05 mg/kg and 0.05 mg/kg of morphine and midazolam,then continuous The index of ideal level of sedation was on the Ramsay scale. The sedation time, the time from discontinuation to ex-tubation, sedation costs, blood pressure were measured. Results The time in midazolam group (6.0±2.4) h was longer than that of propofol (4.6±1.7) h (P<0.01), but there was no significant relationship between morphine-midazolam group (5.6±2.7) h and midazolam group (4.6±1.7) h (P>0.05). The sedation costs in morphine-mi-dazolam group (101.7±20.4) yuan were lower than those of midazolam group (127.7±21.3) yuan (P<0.05) and propofol group(199.7±65.9) yuan (P<0.01). The ratio of hypotension in propofol group (35.4%, 11/31) hap-pened more frequent than that of midazolam group (3.2%, 1/31) (P<0.01) and morphine-midazolam group (9.7%, 3/31) (P<0.05). Conclusions Morphine-midazolam is a safe, effective and economic drug compared with midazolam and propofol used for sedation in patients with mechanical ventilation.
