The efficacy and safety of xiaojin wan plus nimesulide in patients with subacute granulomatous thyroiditis
10.3760/cma.j.issn.1008-6315.2009.11.018
- VernacularTitle:小金丸联合尼美舒利治疗亚急性甲状腺炎疗效观察
- Author:
Fuping LIU
;
Bin CHEN
;
Jan LI
- Publication Type:Journal Article
- Keywords:
Subacute granulomatous thyroiditis;
Chinese medicine;
Nonsteriod anti-inflamatory drugs
- From:
Clinical Medicine of China
2009;25(11):1166-1168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of xiaojin wan plus nimesulide on patients with subacute granu-lomatoas thyroiditis(SAT). Methods 70 SAT cases were divided into nimesulide group(nimesulide 0.1 g,2/d) and combined group(nimesulide 0.1 g,2/d and xiaojin wan 1.2 g,2/d). When the patients' conditions were re-lieved after 3-4 weeks treatment,half doses of the medicines were given in two groups for 8 weeks. The efficacy,safe-ty and relapse rate after withdrawing medicines for 12 weeks were observed. Results The effective rates were 82.90% (29/35) in nimosulide group and 85.7% (30/35)in combined group, but both groups' effective rate was 50.0% (3/6) in patients with high temperature (higher than 39 ℃). The time for fever relieved in two groups were similar (P>0.05), but the thyroid pain smoothing time, normalized rates of blood sedimentation after 1 week therapy, enlarged thyroid or thyroid nodule after 3 week therapy, relapsed rate were significantly more efficacious in combined group than in nimesulide group (P<0.05). There was no severe side effects in the two groups. Conclu-sious There is a synergic effect of xiaojin wan plus nimesulide on patients with SAT, that is an effective and safe therapeutic regimen for SAT patients without high temperature.
