Percutaneous transluminal angioplasty combined with autologous peripheral blood stem cells for lower extremity ischemia
10.3760/cma.j.issn.1007-631X.2009.10.013
- VernacularTitle:血管腔内成形术联合自体外周血干细胞注射治疗下肢缺血性疾病
- Author:
Chen LIN
;
Lie WANG
;
Junmin BAO
;
Chunmei LI
;
Xiangjin XU
- Publication Type:Journal Article
- Keywords:
Arterial occlusive diseases;
Angioplasty;
Peripheral blood stem cell transplantation
- From:
Chinese Journal of General Surgery
2009;24(10):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of percutaneous transluminal angioplasty (PTA)combined with autologous peripheral blood stem cells(PBSC)transplantation in the treatment of lower extremity ischemic disorders.Methods Fourty-two cases of lower extremity ischemic disorders in the treatment group were treated with PTA and autologous peripheral blood stem cells injection and 40 cases in control group were treated with PTA exclusively.Results All the procedures were successful.In treatment group,ABI improved from 0.32 ±0.11 to(at the 3rd month)and 0.49 ±0.13(at the 6th month)(t=-6.765,-6.040,P＜0.05)while TcPO_2 improved from(26.1 ± 2.3)mm Hg to(32.7 ±4.2)mm Hg(at the 3rd month)and(34.5 ±2.7)mm Hg(at the 6th month)(t=-8.901,-14.250,P＜0.05).In control group,ABI improved from 0.30 ±0.12 to 0.47 ±0.15 and 0.47 ±0.130=-5.631,-5.873,P＜0.05)while TcPO_2 increased from(25.9 ±2.4)mm Hg to(28.9 ±2.9)mm Hg(at the 3rd month)and(28.9 ± 2.1)mm Hg(at the 6th month)(t=-5.090,-5.389,P＜0.05).There was significant difference in TcPO_2 on follow-up between the two groups after the treatment(P＜0.05).Conclusion Autologous PBSC transplantation in combination of PTA was effective for the treatment of lower extremity ischemic disorders.PBSC injection helps to increase TcPO_2.
