Risk factors of acute radiation pneumonitis in patients with non-small cell lung cancer after concur-rent three-dimensional conformal radiotherapy and chemotherapy
10.3760/cma.j.issn.1004-4221.2009.06.443
- VernacularTitle:非小细胞肺癌三维适形放疗同期化疗后急性放射性肺炎发生因素分析
- Author:
Tingting ZHUANG
;
Qing LIU
;
Li ZHANG
;
Xiao HU
;
Yan WANG
;
Ming CHEN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms/radiotherapy;
Radiotherapy,three-dimensional conformal;
Lung neoplasms/chemotherapy;
Chemotherapy,concurrent;
Radiation pneumonitis;
Factor analysis
- From:
Chinese Journal of Radiation Oncology
2009;18(6):443-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the incidence and related factors of acute radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) who underwent three-dimensional conformal ra-diotherapy with concurrent chemotherapy. Methods From January 2006 to October 2008, 90 NSCLC pa-tients treated with concurrent chemoradiotherapy were retrospectively reviewed. The clinical characteristics and treatment plan parameters from dose-volume histogram (DVH) were analyzed. Results Grade 1, 2,3, 4 and 5 RP was found in 32.2%, 30.0%, 5.6%, 0% and 1.1% of the patients. Primary tumor loca-tion was the only significant clinical factor in univariate analysis. And significant differences were found when the groups was divided by the mean lung dose (MLD) of 17 Gy, V_(5) of 47% ,V_(10) of 36% ,V_(20) of 24%,V_(30) of 23% and V_(40) of 22%, respectively. Multivariate analysis showed the MLD was the only independent predictive factor of RP. Conclusions Some factors may contribute to the RP. MLD should be set below 17 Gy in three-dimensional conformal radiation, especially when the tumor locates in the lower lobe.
