Effects of cognitive function and neuron morphous in hippocampus of the chronic stress depressed rats with gamma-aminobutyric acid and sertraline
10.3760/cma.j.issn.1674-6554.2009.10.019
- VernacularTitle:γ-氨基丁酸联合舍曲林对慢性应激抑郁大鼠认知功能及海马神经元形态的影响
- Author:
Chunying ZHOU
;
Yongjian GU
- Publication Type:Journal Article
- Keywords:
Chronic stress;
Depression;
Gamma-aminobutyric acid;
Hippocampus;
Cognition
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2009;18(10):912-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cognitive function and neuron morphous in hippocampus of the chronic stress depressed rats with gamma-aminobutyric acid and sertraline.Methods Using the chronic mild unpredictable stress to make the model of the chronic stress depressed rats.Sample group,sertraline group,GABA group and research group were gave by saline,sertraline,GABA,GABA and sertraline i.p.respectively for 21 days.Control group reeepted no any stress and drugs.Using open-field test and electric maze test to detect the behavior and memory function of the rats.Using Nissl staining to observe the pyramidal neuron morphous in CA1 and CA3 region of the hippocampus.Results After stress,the squares crossing,rears,grooming movement of the four groups accecepted stress were decreased compared with the control (P ＜ 0.05).After treatment,the squares crossing(respective for 57.25±18.79,39.00±13.69),rears(respective for 23.25±7.01,16.75±4.71),grooming movement(respective for 2.25±0.46,2.25±1.04),number of correct reaction (respective for 17.00±1.93,16.88±2.64) and latency time (respective for 172.88±26.91,206.00±33.54) of the research group and sertraline group were better than sample group(P ＜ 0.05 or 0.01).GABA group showed no significant improvemerit except for the reduced latency time compared with the sample group(P＜ 0.05).Compared with the control,the morphous,numbers and alignment of pyramidal neuron in CA1 and CA3 in hippocampus of the sertraline group,GABA group and research group were improve with different level,all the better in research group.Conclusion GABA with sertraline can improve the cognitive function of the chronic stress depressed rats by protect the neuron in hippocampus.
